Human Brain
    Proteome Database
 

  The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. In a human, the cerebral cortex contains approximately 15¨C33 billion neurons, each connected by synapses to several thousand other neurons.The function of the brain can be understood as information flow and implementation of algorithms. The lobes of the brain have been shown to be related to different brain functions, including memory, motivation and learning. Glioma is a type of tumor that starts in the brain and a brain glioma can cause headaches, vomiting, seizures, and cranial nerve disorders. Proteomics investigation of brain regions could provide molecular insights into brain functions and brain cancer mechanism.

  In order to explore the molecular mechanism of brain and related diseases, we collected various tissue samples from subjects, and analyzed iTRAQ¨Cbased quantification proteome of them. The detailed information was given in this database.

1.  Proteomics data from thefrontal lobe and temporal lobe samples obtained from 4 health individuals (each sample analyzed by triplicates), were used to produce the human frontal lobe and temporal lobequantification proteome. Protein expression levels differences between normal frontal lobe and temporal lobecould be obtained in the database.
2.  Proteomics data fromdifferent types of glioma tissues, including temporal astrocytomas, frontal astrocytomas, frontal oligodendrogliomas, frontal anaplastic oligodendrogliomas and frontal glioblastoma, were used to explore protein expression level differences of the same glioma type in frontal lobe and temporal lobe and protein expression level differences of different glioma types in frontal lobe or temporal lobe.
3.  Proteomics data from pooledpseudoprogression sample from 3 individualsand pooled newly diagnosed glioblastomasample from 3 individuals was used for analyze proteins that are differentially expressed between groups.
4.  Proteomics data frompooled exophytic tissue sample from 6 individuals and pooled endophytic tissue sample from 6 individuals were used to explore differentially expressed proteins in exophytic and endophytic chordoma.

  This dataset will offer a useful baseline reference for proteomics research of brain and related brain cancer.


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Institute of Basic Medical Sciences Chinese Academy of Medical Sciences
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